Administration with L-glutamine and L-glutathione protects the nitrergic innervation of the penile tissue of diabetic rats

Erectile dysfunction is caused due to neuropathy, resulting from a high oxidative stress, in this way treatment with antioxidants may be promising. Aim of work was investigate the effects administration 2% L-glutamine and 1% L-glutathione on penile tissue diabetic rats analyzing nerve fibers that expressing Nitric Oxide Synthase Neuronal (nNOS). Forty-eight male Wistar distributed into six groups were used: normoglycemic, diabetic, normoglycemic administered L-glutamine, L-glutathione, L-glutathione. After 120 days experimental period, animals euthanized, tissues collected processed for subsequent immunohistochemical procedure (nNOS) posterior varicosities morphometry analysis. Diabetic displayed larger varicosity areas 14 15% compared group (p < 0.05). On other hand, promoted reduction 3.3% 2.4% We concluded both administrations exerted protective effect nitrergic innervation rats, which can have positive impact erectile function their use should better investigated.